Overview
Definition
Bone marrow failure syndrome causing pancytopenia.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Idiopathic autoimmune, Toxins (Benzene), Drugs (Chloramphenicol), Parvovirus B19.
Clinical Symptoms
- Fatigue (anemia)
- bleeding/petechiae (thrombocytopenia)
- recurrent infections (neutropenia).
Clinical Approach
Diagnosis
- Bone marrow biopsy (hypocellular
- fat-filled).
Management
- Immunosuppression (ATG
- Cyclosporine)
- Bone marrow transplant.
Complications
- Fatal bleeding or severe sepsis.