Overview
Definition
Antibody-mediated destruction of RBCs.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Warm (IgG - idiopathic, SLE, CLL), Cold (IgM - Mycoplasma, EBV).
Clinical Symptoms
- Fatigue
- jaundice
- dark urine.
Clinical Approach
Diagnosis
- Positive Direct Antiglobulin Test (DAT/Coombs test).
Management
- Warm: Corticosteroids
- Rituximab. Cold: Avoid cold
- Rituximab.
Complications
- Severe symptomatic anemia.