Glucagonoma

Endocrinology

Overview

Definition

Glucagon-secreting tumor of the pancreas.

Epidemiology

Varies globally depending on genetics, environment, or exposure.

Etiology & Risk Factors

  • Malignant neuroendocrine tumor.

Clinical Symptoms

  • Mild diabetes
  • Necrolytic migratory erythema (red blistering rash)
  • weight loss
  • DVT.

Clinical Approach

Diagnosis

  • Markedly elevated fasting glucagon.

Management

  • Octreotide
  • Surgical resection.

Complications

  • Metastasis (usually to liver).