Overview
Definition
X-linked recessive enzymopathy causing episodic hemolytic anemia.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Genetic mutation protecting against malaria but susceptible to oxidative stress.
Clinical Symptoms
- Dark urine
- jaundice
- back pain following exposure to fava beans
- sulfa drugs
- or infection.
Clinical Approach
Diagnosis
- G6PD assay (wait until acute hemolysis resolves)
- Smear (Heinz bodies
- Bite cells).
Management
- Avoid oxidative triggers
- supportive during crises.
Complications
- Acute renal failure from hemoglobinuria.