Overview
Definition
Acute, immune-mediated polyneuropathy causing rapidly progressive weakness.
Epidemiology
Rare, incidence 1-2 per 100,000.
Etiology & Risk Factors
- Post-infectious autoimmune response (Campylobacter jejuni, CMV, EBV)
Clinical Symptoms
- Ascending symmetric weakness
- Areflexia
- Paresthesias
- Autonomic dysfunction
Clinical Approach
Diagnosis
- CSF analysis (Albuminocytologic dissociation)
- EMG/NCS
Management
- IVIG or Plasmapheresis
- Supportive care (often intubation)
Complications
- Respiratory failure
- Cardiac arrhythmias
- Residual weakness