Overview
Definition
Iron overload disorder.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Autosomal recessive mutation in HFE gene.
Clinical Symptoms
- Bronze diabetes (hyperpigmentation
- diabetes)
- hepatomegaly
- arthropathy (2nd/3rd MCP joints).
Clinical Approach
Diagnosis
- High transferrin saturation
- High ferritin
- HFE gene test.
Management
- Therapeutic phlebotomy.
Complications
- Hepatocellular carcinoma
- Restrictive cardiomyopathy.