Overview
Definition
Functional renal failure in patients with severe liver disease.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Splanchnic vasodilation causing profound renal vasoconstriction in cirrhosis.
Clinical Symptoms
- Rapid rise in creatinine in a cirrhotic patient with ascites
- bland urine.
Clinical Approach
Diagnosis
- Diagnosis of exclusion (failure to respond to fluid challenge).
Management
- Midodrine
- Octreotide
- Albumin
- Liver transplant (curative).
Complications
- Death.