Overview
Definition
Viral infection that attacks the body's immune system, specifically CD4 T cells.
Epidemiology
~38 million people globally living with HIV.
Etiology & Risk Factors
- Human Immunodeficiency Virus (sexual contact, blood, perinatal)
Clinical Symptoms
- Acute: Flu-like symptoms
- Chronic: Asymptomatic
- AIDS: Opportunistic infections (PCP, Kaposi sarcoma)
Clinical Approach
Diagnosis
- HIV-1/2 Antigen/Antibody combo assay
- HIV Viral Load
- CD4 count
Management
- Antiretroviral therapy (ART) - Integrase inhibitors, NRTIs
- PrEP for prevention
Complications
- AIDS
- Opportunistic infections
- Malignancies