IgA Nephropathy (Berger Disease)

Nephrology

Overview

Definition

Most common cause of primary glomerulonephritis globally.

Epidemiology

Most common in Asians and Caucasians, affects males more than females.

Etiology & Risk Factors

  • Deposition of IgA immune complexes in the mesangium

Clinical Symptoms

  • Gross hematuria concurrent with respiratory/GI infections
  • Mild proteinuria

Clinical Approach

Diagnosis

  • Renal biopsy (mesangial IgA deposits on immunofluorescence)

Management

  • ACE inhibitors/ARBs
  • Fish oil
  • Immunosuppressants if progressive

Complications

  • Chronic kidney disease
  • End-stage renal disease (in 20-40% over 20 years)