Overview
Definition
Autoimmune presynaptic disorder of neuromuscular junction.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Antibodies against voltage-gated calcium channels, strongly paraneoplastic (Small Cell Lung Cancer).
Clinical Symptoms
- Proximal muscle weakness that IMPROVES with repeated use
- dry mouth.
Clinical Approach
Diagnosis
- EMG (incremental response).
Management
- Treat underlying cancer
- 3,4-Diaminopyridine.
Complications
- Severe weakness
- respiratory failure.