Overview
Definition
Necrotizing vasculitis of small vessels.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Autoimmune (p-ANCA/MPO-ANCA).
Clinical Symptoms
- Palpable purpura
- hemoptysis
- hematuria.
Clinical Approach
Diagnosis
- Renal biopsy (pauci-immune crescentic GN).
Management
- Corticosteroids
- Cyclophosphamide
- Rituximab.
Complications
- Alveolar hemorrhage
- Renal failure.