Overview
Definition
Overlap syndrome with features of SLE, systemic sclerosis, and polymyositis.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Autoimmune.
Clinical Symptoms
- Raynaud's
- swollen hands
- arthritis
- myositis.
Clinical Approach
Diagnosis
- High titers of anti-U1 RNP antibodies.
Management
- Corticosteroids
- Immunosuppressants.
Complications
- Pulmonary hypertension (major cause of death).