Multiple Endocrine Neoplasia Type 1 (MEN 1)

Endocrinology

Overview

Definition

Inherited disorder causing tumors in endocrine glands.

Epidemiology

Varies globally. Often age and lifestyle dependent.

Etiology & Risk Factors

  • Mutation in MEN1 gene (autosomal dominant).

Clinical Symptoms

  • 3 P's: Parathyroid (hypercalcemia)
  • Pituitary (prolactinoma)
  • Pancreatic (gastrinoma).

Clinical Approach

Diagnosis

  • Genetic testing
  • hormone levels
  • imaging.

Management

  • Surgical resection of tumors
  • medical management.

Complications

  • Malignancy
  • severe peptic ulcer disease (Zollinger-Ellison).