Overview
Definition
Cancer originating in the ovaries, fallopian tubes, or peritoneum.
Epidemiology
Highest mortality of all gynecologic cancers.
Etiology & Risk Factors
- BRCA1/BRCA2 mutations
- Nulliparity
- Endometriosis
Clinical Symptoms
- Vague symptoms: Bloating, early satiety, pelvic pain, changes in bowel habits
Clinical Approach
Diagnosis
- Pelvic ultrasound
- Elevated CA-125
- Surgical exploration (definitive)
Management
- Optimal surgical cytoreduction (debulking)
- Platinum-based chemotherapy
- PARP inhibitors (for BRCA+)
Complications
- Extensive peritoneal carcinomatosis
- Bowel obstruction
- Malignant ascites