Overview
Definition
Disorder of accelerated bone remodeling.
Epidemiology
Varies globally. Often age and lifestyle dependent.
Etiology & Risk Factors
- Genetics, viral etiology suspected.
Clinical Symptoms
- Bone pain
- bowing of long bones
- increasing hat size
- hearing loss.
Clinical Approach
Diagnosis
- Elevated Alkaline Phosphatase (isolated)
- X-ray (thickened bone).
Management
- Bisphosphonates (Zoledronic acid).
Complications
- Osteosarcoma
- fractures
- deafness.