Overview
Definition
Defect in the gastric or duodenal mucosa that extends through the muscularis mucosae.
Epidemiology
Lifetime prevalence of 5-10%.
Etiology & Risk Factors
- Helicobacter pylori infection
- NSAID use
- Zollinger-Ellison syndrome
Clinical Symptoms
- Epigastric pain
- Nausea
- Hematemesis
- Melena
Clinical Approach
Diagnosis
- Upper Endoscopy
- H. pylori testing
Management
- PPIs
- H. pylori eradication (Triple/Quadruple therapy)
Complications
- Perforation
- Bleeding
- Gastric outlet obstruction