Overview
Definition
Systemic necrotizing vasculitis of medium-sized arteries.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Autoimmune, strong association with Hepatitis B (30%).
Clinical Symptoms
- Fever
- weight loss
- mononeuritis multiplex
- livedo reticularis
- renal/visceral ischemia.
Clinical Approach
Diagnosis
- Tissue biopsy
- Angiography (microaneurysms - 'rosary sign').
Management
- High-dose corticosteroids
- Cyclophosphamide.
Complications
- Renal failure
- mesenteric ischemia.