Primary Hyperaldosteronism

Endocrinology

Overview

Definition

Excess autonomous production of aldosterone.

Epidemiology

Varies globally depending on genetics, environment, or exposure.

Etiology & Risk Factors

  • Adrenal adenoma (Conn syndrome) or bilateral hyperplasia.

Clinical Symptoms

  • Refractory hypertension
  • hypokalemia
  • metabolic alkalosis.

Clinical Approach

Diagnosis

  • High Aldosterone-to-Renin ratio.

Management

  • Spironolactone/Eplerenone
  • Adrenalectomy (if unilateral).

Complications

  • Cardiovascular events from uncontrolled hypertension.