Primary Sclerosing Cholangitis

Gastroenterology

Overview

Definition

Inflammation, stricturing, and fibrosis of intra/extrahepatic bile ducts.

Epidemiology

Varies globally depending on genetics, environment, or exposure.

Etiology & Risk Factors

  • Autoimmune, strongly associated with Ulcerative Colitis (>80%).

Clinical Symptoms

  • Pruritus
  • jaundice
  • fatigue.

Clinical Approach

Diagnosis

  • MRCP/ERCP (beaded appearance of bile ducts).

Management

  • Endoscopic dilation of strictures
  • Liver transplant.

Complications

  • Cholangiocarcinoma
  • Liver cirrhosis.