Overview
Definition
Most severe form of SJS.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Medications.
Clinical Symptoms
- Diffuse epidermal sloughing/necrosis
- positive Nikolsky sign
- >30% body surface area detachment.
Clinical Approach
Diagnosis
- Clinical
- Skin biopsy.
Management
- Burn unit intensive care
- aggressive fluid resuscitation
- IVIG.
Complications
- High mortality rate from sepsis and fluid loss.