Overview
Definition
Gastrin-secreting tumor (gastrinoma) causing severe acid hypersecretion.
Epidemiology
Varies globally depending on genetics, environment, or exposure.
Etiology & Risk Factors
- Usually a sporadic tumor in duodenum/pancreas, or MEN 1 syndrome.
Clinical Symptoms
- Severe
- refractory peptic ulcers (often multiple or distal)
- chronic diarrhea.
Clinical Approach
Diagnosis
- Fasting serum gastrin
- Secretin stimulation test.
Management
- High-dose PPIs
- Surgical resection of tumor.
Complications
- Perforated peptic ulcer.