Dosing & Administration
Adult Dose
100-300 mg PO daily (max 800 mg/day).
Pediatric Dose
Tumor lysis: 10 mg/kg/day divided.
Renal Adjustment
CrCl 10-20: Max 200 mg/day. CrCl < 10: Max 100 mg/day.
Hepatic Adjustment
No adjustment necessary.
Safety & Special Populations
Pregnancy Category
C
Lactation Safety
Compatible.
Contraindications & Adverse Effects
Contraindications
- Hypersensitivity
Common Adverse Effects
- Severe rash (SJS/TEN)
- Hepatotoxicity
- Acute gout flare (when initiated)