Dosing & Administration
Adult Dose
Vaginal: 150 mg PO once. Systemic: 200-800 mg PO/IV daily.
Pediatric Dose
6-12 mg/kg PO/IV daily.
Renal Adjustment
CrCl ≤ 50: Decrease dose by 50%.
Hepatic Adjustment
Use caution.
Safety & Special Populations
Pregnancy Category
D - Avoid for systemic infections; single 150mg dose for yeast infection generally accepted.
Lactation Safety
Compatible.
Contraindications & Adverse Effects
Contraindications
- Concurrent administration of CYP3A4 substrates that prolong QT
Common Adverse Effects
- Hepatotoxicity
- QT prolongation
- Headache