Flumazenil (Romazicon)

Toxicology (Benzodiazepine Antagonist)

Dosing & Administration

Adult Dose

0.2 mg IV over 15 seconds. May repeat 0.2-0.5 mg every minute (Max 3 mg).

Pediatric Dose

0.01 mg/kg IV (max 0.2 mg/dose).

Renal Adjustment

No adjustment necessary.

Hepatic Adjustment

No adjustment necessary.

Safety & Special Populations

Pregnancy Category

C

Lactation Safety

Unknown.

Contraindications & Adverse Effects

Contraindications

  • TCA overdose
  • Patients given benzos for status epilepticus
  • Signs of increased ICP

Common Adverse Effects

  • Seizures (especially in chronic benzo users)
  • Agitation
  • Arrhythmias