Dosing & Administration
Adult Dose
400-800 mg PO every 6-8 hours (Max 3200 mg/day).
Pediatric Dose
5-10 mg/kg PO every 6-8 hours (Max 40 mg/kg/day).
Renal Adjustment
Avoid in severe renal impairment or acute kidney injury.
Hepatic Adjustment
Use caution.
Safety & Special Populations
Pregnancy Category
C (Avoid after 30 weeks gestation).
Lactation Safety
Compatible.
Contraindications & Adverse Effects
Contraindications
- CABG perioperative pain
- History of GI bleeding
- Severe renal disease
Common Adverse Effects
- GI ulcers
- Nephrotoxicity
- Increased cardiovascular risk