Dosing & Administration
Adult Dose
0.5-1 mg/kg/day PO divided BID for 15-20 weeks.
Pediatric Dose
Same as adult (for adolescents >12 yrs).
Renal Adjustment
No adjustment necessary.
Hepatic Adjustment
Contraindicated in severe liver disease.
Safety & Special Populations
Pregnancy Category
X - Extremely teratogenic (requires iPLEDGE registration).
Lactation Safety
Contraindicated.
Contraindications & Adverse Effects
Contraindications
- Pregnancy
- Tetracycline use (pseudotumor cerebri risk)
Common Adverse Effects
- Dry skin/lips
- Hypertriglyceridemia
- Myalgias
- Depression/suicidality risk (debated)