Dosing & Administration
Adult Dose
1 tablet (90/400 mg) PO daily for 8-24 weeks depending on cirrhosis/prior treatment.
Pediatric Dose
Weight-based for children >= 3 years.
Renal Adjustment
No adjustment necessary even in ESRD (recent guideline updates).
Hepatic Adjustment
No adjustment necessary for Child-Pugh A, B, or C.
Safety & Special Populations
Pregnancy Category
B
Lactation Safety
Unknown.
Contraindications & Adverse Effects
Contraindications
- Concurrent amiodarone use (fatal bradycardia)
Common Adverse Effects
- Headache
- Fatigue
- Asthenia