Dosing & Administration
Adult Dose
10-40 mg PO daily.
Pediatric Dose
0.07 mg/kg (up to 5 mg) PO daily.
Renal Adjustment
CrCl < 30: Start at 2.5-5 mg daily.
Hepatic Adjustment
No adjustment necessary.
Safety & Special Populations
Pregnancy Category
D - Absolutely contraindicated in 2nd/3rd trimesters.
Lactation Safety
Probably compatible, but lack of data.
Contraindications & Adverse Effects
Contraindications
- History of angioedema
- Bilateral renal artery stenosis
- Pregnancy
Common Adverse Effects
- Dry cough
- Hyperkalemia
- Angioedema
- Renal impairment