Dosing & Administration
Adult Dose
300 mg PO TID initially. Titrate to target serum level (0.6-1.2 mEq/L).
Pediatric Dose
15-60 mg/kg/day divided (specialist dosing).
Renal Adjustment
Requires significant adjustment; contraindicated in severe impairment.
Hepatic Adjustment
No adjustment necessary (not metabolized by liver).
Safety & Special Populations
Pregnancy Category
D - Associated with Ebstein's anomaly (first trimester).
Lactation Safety
Avoid if possible (transferred in breast milk, infant toxicity).
Contraindications & Adverse Effects
Contraindications
- Severe cardiovascular or renal disease
- Dehydration
- Sodium depletion
Common Adverse Effects
- Tremor
- Hypothyroidism
- Nephrogenic diabetes insipidus
- Toxicity (ataxia, confusion)