Dosing & Administration
Adult Dose
4 mg PO initially, then 2 mg after each loose stool (Max 16 mg/day).
Pediatric Dose
Avoid in < 2 yrs. Weight-based dosing for > 2 yrs.
Renal Adjustment
No adjustment necessary.
Hepatic Adjustment
Use caution (can precipitate hepatic encephalopathy).
Safety & Special Populations
Pregnancy Category
C
Lactation Safety
Compatible.
Contraindications & Adverse Effects
Contraindications
- Dysentery (bloody diarrhea with high fever)
- Pseudomembranous colitis
Common Adverse Effects
- Constipation
- Abdominal cramps
- QT prolongation / Torsades (at massive overdose)