Dosing & Administration
Adult Dose
50-100 mg PO daily.
Pediatric Dose
0.7 mg/kg PO daily (up to 50 mg).
Renal Adjustment
No specific initial adjustment, but monitor for hyperkalemia and acute injury.
Hepatic Adjustment
Start 25 mg daily in mild-mod impairment.
Safety & Special Populations
Pregnancy Category
D - Absolutely contraindicated in 2nd/3rd trimesters.
Lactation Safety
Unknown, avoid if possible.
Contraindications & Adverse Effects
Contraindications
- Pregnancy
- Concurrent aliskiren use in diabetics
Common Adverse Effects
- Hyperkalemia
- Dizziness
- Angioedema (lower risk than ACEI)