Dosing & Administration
Adult Dose
Pre-eclampsia: 4-6g IV loading, then 1-2g/hr. Asthma/Torsades: 1-2g IV over 15 mins.
Pediatric Dose
Asthma: 25-50 mg/kg IV over 20 mins (max 2g).
Renal Adjustment
Renally cleared. Reduce maintenance dose in severe impairment; monitor Mg levels.
Hepatic Adjustment
No adjustment necessary.
Safety & Special Populations
Pregnancy Category
D - Used specifically for pre-eclampsia/eclampsia, but avoid prolonged use (>5-7 days) due to fetal bone effects.
Lactation Safety
Compatible.
Contraindications & Adverse Effects
Contraindications
- Myasthenia gravis
- Heart block
Common Adverse Effects
- Flushing
- Loss of deep tendon reflexes (toxicity)
- Respiratory depression (severe toxicity)