Dosing & Administration
Adult Dose
RA: 7.5-15 mg PO ONCE WEEKLY (never daily). Ectopic: 50 mg/m2 IM.
Pediatric Dose
JIA: 10 mg/m2 PO ONCE WEEKLY.
Renal Adjustment
CrCl 10-50: Reduce dose by 50%. CrCl < 10: Avoid.
Hepatic Adjustment
Avoid in severe liver disease.
Safety & Special Populations
Pregnancy Category
X - Teratogenic / Abortifacient.
Lactation Safety
Contraindicated.
Contraindications & Adverse Effects
Contraindications
- Pregnancy
- Breastfeeding
- Severe renal/hepatic impairment
- Bone marrow suppression
Common Adverse Effects
- Hepatotoxicity
- Stomatitis
- Bone marrow suppression
- Pulmonary fibrosis