Dosing & Administration
Adult Dose
2-4 mg IV every 2-4 hours. 15-30 mg PO every 4 hours.
Pediatric Dose
0.05-0.1 mg/kg IV every 2-4 hours.
Renal Adjustment
CrCl < 50: Decrease dose by 25-50% (active metabolites accumulate).
Hepatic Adjustment
Use caution in severe impairment.
Safety & Special Populations
Pregnancy Category
C
Lactation Safety
Compatible (monitor infant for sedation).
Contraindications & Adverse Effects
Contraindications
- Severe respiratory depression
- Paralytic ileus
Common Adverse Effects
- Respiratory depression
- Constipation
- Pruritus
- Hypotension