Dosing & Administration
Adult Dose
20-40 mg PO daily before a meal.
Pediatric Dose
1 mg/kg/day PO (max 40 mg/day).
Renal Adjustment
No adjustment necessary.
Hepatic Adjustment
Consider max 20 mg/day in severe hepatic impairment.
Safety & Special Populations
Pregnancy Category
C
Lactation Safety
Compatible.
Contraindications & Adverse Effects
Contraindications
- Concurrent use with rilpivirine
Common Adverse Effects
- Headache
- C. diff risk
- Hypomagnesemia (with long-term use)