Promethazine (Phenergan)

Gastroenterology / Allergy (Antiemetic / H1 Antagonist)

Dosing & Administration

Adult Dose

12.5-25 mg PO/IM/PR every 4-6 hours PRN. Avoid IV if possible due to tissue necrosis risk.

Pediatric Dose

0.25-0.5 mg/kg PO/IM/PR every 4-6 hours (Contraindicated < 2 yrs).

Renal Adjustment

No adjustment necessary.

Hepatic Adjustment

Use caution.

Safety & Special Populations

Pregnancy Category

C

Lactation Safety

Use caution (can cause infant sedation).

Contraindications & Adverse Effects

Contraindications

  • Children < 2 years (fatal respiratory depression)

Common Adverse Effects

  • Sedation
  • Severe tissue injury (if given IV)
  • Extrapyramidal symptoms