Dosing & Administration
Adult Dose
UTI/Skin: 1 DS tab (800/160 mg) PO BID.
Pediatric Dose
8-12 mg/kg/day (of TMP component) PO divided BID.
Renal Adjustment
CrCl 15-30: Reduce dose by 50%. CrCl < 15: Not recommended.
Hepatic Adjustment
Use caution.
Safety & Special Populations
Pregnancy Category
D - Avoid in 1st trimester and at term (kernicterus).
Lactation Safety
Avoid if nursing infant < 2 months old.
Contraindications & Adverse Effects
Contraindications
- Sulfa allergy
- Megaloblastic anemia due to folate deficiency
Common Adverse Effects
- Stevens-Johnson Syndrome (SJS)
- Hyperkalemia
- Bone marrow suppression