Dosing & Administration
Adult Dose
50-100 mg PO (repeat once after 2h if needed, max 200 mg/day). SQ: 6 mg (max 12 mg/day).
Pediatric Dose
Not FDA approved < 18 yrs, but sometimes used off-label.
Renal Adjustment
No adjustment necessary.
Hepatic Adjustment
Max 50 mg PO single dose in mild-mod impairment.
Safety & Special Populations
Pregnancy Category
C
Lactation Safety
Compatible (discard milk for 8h optionally to minimize exposure).
Contraindications & Adverse Effects
Contraindications
- Ischemic heart disease
- Prinzmetal angina
- Uncontrolled hypertension
- History of stroke
Common Adverse Effects
- Chest tightness / pressure
- Flushing
- Tingling