Dosing & Administration
Adult Dose
50-100 mg PO every 4-6 hours (max 400 mg/day).
Pediatric Dose
Contraindicated in children < 12 years.
Renal Adjustment
CrCl < 30: Increase dosing interval to every 12 hours (max 200 mg/day).
Hepatic Adjustment
Cirrhosis: 50 mg every 12 hours.
Safety & Special Populations
Pregnancy Category
C
Lactation Safety
Avoid.
Contraindications & Adverse Effects
Contraindications
- Children < 12 yrs
- Concurrent MAOI use
- Severe respiratory depression
Common Adverse Effects
- Lowers seizure threshold
- Serotonin syndrome risk
- Nausea
- Constipation