Dosing & Administration
Adult Dose
24/26 mg to 97/103 mg PO BID.
Pediatric Dose
Weight-based for pediatric heart failure.
Renal Adjustment
eGFR < 30: Start at 24/26 mg BID.
Hepatic Adjustment
Child-Pugh B: Start at 24/26 mg BID. Child-Pugh C: Avoid.
Safety & Special Populations
Pregnancy Category
D - Teratogenic.
Lactation Safety
Not recommended.
Contraindications & Adverse Effects
Contraindications
- History of angioedema
- Concurrent ACE inhibitor use (must wait 36 hours after stopping ACEi)
Common Adverse Effects
- Hypotension
- Hyperkalemia
- Angioedema
- Renal impairment