Dosing & Administration
Adult Dose
Initial: 2-5 mg PO daily. Titrate to target INR (usually 2.0-3.0).
Pediatric Dose
0.1-0.2 mg/kg/day PO.
Renal Adjustment
No specific adjustment, but monitor INR closely.
Hepatic Adjustment
Use extreme caution; lower doses required.
Safety & Special Populations
Pregnancy Category
X - Teratogenic (except mechanical valves where benefits may outweigh).
Lactation Safety
Compatible.
Contraindications & Adverse Effects
Contraindications
- Pregnancy
- Bleeding tendencies
- Recent neurosurgery
Common Adverse Effects
- Bleeding
- Skin necrosis
- Purple toe syndrome