IV Compatibility Matrix

Check Y-site and syringe compatibility between medications and diluents.

Ceftriaxone＋Calcium Gluconate

Forms calcium-ceftriaxone precipitates. Fatal in neonates.

Incompatible

Ceftriaxone＋Lactated Ringer's

LR contains calcium. Forms precipitates.

Incompatible

Heparin＋Dopamine

Y-site compatible.

Compatible

Heparin＋Gentamicin

Precipitates visually.

Incompatible

Insulin (Regular)＋Normal Saline

Standard diluent.

Compatible

Vancomycin＋Piperacillin/Tazobactam

Y-site incompatible; precipitates.

Incompatible

Magnesium Sulfate＋Lactated Ringer's

Stable.

Compatible

Epinephrine＋Sodium Bicarbonate

Alkaline pH inactivates catecholamines.

Incompatible

Norepinephrine＋Pantoprazole

Precipitates visually (pH dependent).

Incompatible

Norepinephrine＋Furosemide

Precipitates visually (pH dependent).

Incompatible

Norepinephrine＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Norepinephrine＋Magnesium Sulfate

Physical precipitation or chemical degradation may occur.

Incompatible

Norepinephrine＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Norepinephrine＋Sodium Bicarbonate

Alkaline pH inactivates catecholamines.

Incompatible

Norepinephrine＋Ceftriaxone

Physical precipitation or chemical degradation may occur.

Incompatible

Norepinephrine＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Norepinephrine＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Norepinephrine＋Meropenem

Compatibility depends on specific concentrations or diluents used.

Caution

Epinephrine＋Pantoprazole

Compatibility depends on specific concentrations or diluents used.

Caution

Epinephrine＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Epinephrine＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Epinephrine＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Epinephrine＋Potassium Chloride

Physical precipitation or chemical degradation may occur.

Incompatible

Epinephrine＋Sodium Bicarbonate

Alkaline pH inactivates catecholamines.

Incompatible

Epinephrine＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Epinephrine＋Piperacillin/Tazobactam

Physical precipitation or chemical degradation may occur.

Incompatible

Epinephrine＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Epinephrine＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Dopamine＋Pantoprazole

Y-site compatible in standard concentrations.

Compatible

Dopamine＋Furosemide

Compatibility depends on specific concentrations or diluents used.

Caution

Dopamine＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Dopamine＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Dopamine＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Dopamine＋Sodium Bicarbonate

Alkaline pH inactivates catecholamines.

Incompatible

Dopamine＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Dopamine＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Dopamine＋Vancomycin

Physical precipitation or chemical degradation may occur.

Incompatible

Dopamine＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Dobutamine＋Pantoprazole

Precipitates visually (pH dependent).

Incompatible

Dobutamine＋Furosemide

Precipitates visually (pH dependent).

Incompatible

Dobutamine＋Calcium Gluconate

Compatibility depends on specific concentrations or diluents used.

Caution

Dobutamine＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Dobutamine＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Dobutamine＋Sodium Bicarbonate

Alkaline pH inactivates catecholamines.

Incompatible

Dobutamine＋Ceftriaxone

Physical precipitation or chemical degradation may occur.

Incompatible

Dobutamine＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Dobutamine＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Dobutamine＋Meropenem

Physical precipitation or chemical degradation may occur.

Incompatible

Heparin＋Pantoprazole

Physical precipitation or chemical degradation may occur.

Incompatible

Heparin＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Heparin＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Heparin＋Magnesium Sulfate

Compatibility depends on specific concentrations or diluents used.

Caution

Heparin＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Heparin＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Heparin＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Heparin＋Piperacillin/Tazobactam

Physical precipitation or chemical degradation may occur.

Incompatible

Heparin＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Heparin＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Insulin＋Pantoprazole

Y-site compatible in standard concentrations.

Compatible

Insulin＋Furosemide

Physical precipitation or chemical degradation may occur.

Incompatible

Insulin＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Insulin＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Insulin＋Potassium Chloride

Compatibility depends on specific concentrations or diluents used.

Caution

Insulin＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Insulin＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Insulin＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Insulin＋Vancomycin

Physical precipitation or chemical degradation may occur.

Incompatible

Insulin＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Propofol＋Pantoprazole

Precipitates visually (pH dependent).

Incompatible

Propofol＋Furosemide

Precipitates visually (pH dependent).

Incompatible

Propofol＋Calcium Gluconate

Risk of cracking the lipid emulsion; generally avoid mixing if possible.

Caution

Propofol＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Propofol＋Potassium Chloride

Risk of cracking the lipid emulsion; generally avoid mixing if possible.

Caution

Propofol＋Sodium Bicarbonate

Compatibility depends on specific concentrations or diluents used.

Caution

Propofol＋Ceftriaxone

Risk of cracking the lipid emulsion; generally avoid mixing if possible.

Caution

Propofol＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Propofol＋Vancomycin

Risk of cracking the lipid emulsion; generally avoid mixing if possible.

Caution

Propofol＋Meropenem

Physical precipitation or chemical degradation may occur.

Incompatible

Fentanyl＋Pantoprazole

Physical precipitation or chemical degradation may occur.

Incompatible

Fentanyl＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Fentanyl＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Fentanyl＋Magnesium Sulfate

Physical precipitation or chemical degradation may occur.

Incompatible

Fentanyl＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Fentanyl＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Fentanyl＋Ceftriaxone

Compatibility depends on specific concentrations or diluents used.

Caution

Fentanyl＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Fentanyl＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Fentanyl＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Midazolam＋Pantoprazole

Y-site compatible in standard concentrations.

Compatible

Midazolam＋Furosemide

Physical precipitation or chemical degradation may occur.

Incompatible

Midazolam＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Midazolam＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Midazolam＋Potassium Chloride

Physical precipitation or chemical degradation may occur.

Incompatible

Midazolam＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Midazolam＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Midazolam＋Piperacillin/Tazobactam

Compatibility depends on specific concentrations or diluents used.

Caution

Midazolam＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Midazolam＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Dexmedetomidine＋Pantoprazole

Precipitates visually (pH dependent).

Incompatible

Dexmedetomidine＋Furosemide

Precipitates visually (pH dependent).

Incompatible

Dexmedetomidine＋Calcium Gluconate

Physical precipitation or chemical degradation may occur.

Incompatible

Dexmedetomidine＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Dexmedetomidine＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Dexmedetomidine＋Sodium Bicarbonate

Physical precipitation or chemical degradation may occur.

Incompatible

Dexmedetomidine＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Dexmedetomidine＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Dexmedetomidine＋Vancomycin

Compatibility depends on specific concentrations or diluents used.

Caution

Dexmedetomidine＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Amiodarone＋Pantoprazole

Y-site compatible in standard concentrations.

Compatible

Amiodarone＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Amiodarone＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Amiodarone＋Magnesium Sulfate

Physical precipitation or chemical degradation may occur.

Incompatible

Amiodarone＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Amiodarone＋Sodium Bicarbonate

Known incompatibility; avoid Y-site administration.

Incompatible

Amiodarone＋Ceftriaxone

Physical precipitation or chemical degradation may occur.

Incompatible

Amiodarone＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Amiodarone＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Amiodarone＋Meropenem

Compatibility depends on specific concentrations or diluents used.

Caution

Diltiazem＋Pantoprazole

Compatibility depends on specific concentrations or diluents used.

Caution

Diltiazem＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Diltiazem＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Diltiazem＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Diltiazem＋Potassium Chloride

Physical precipitation or chemical degradation may occur.

Incompatible

Diltiazem＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Diltiazem＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Diltiazem＋Piperacillin/Tazobactam

Physical precipitation or chemical degradation may occur.

Incompatible

Diltiazem＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Diltiazem＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Nicardipine＋Pantoprazole

Precipitates visually (pH dependent).

Incompatible

Nicardipine＋Furosemide

Precipitates visually (pH dependent).

Incompatible

Nicardipine＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Nicardipine＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Nicardipine＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Nicardipine＋Sodium Bicarbonate

Physical precipitation or chemical degradation may occur.

Incompatible

Nicardipine＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Nicardipine＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Nicardipine＋Vancomycin

Physical precipitation or chemical degradation may occur.

Incompatible

Nicardipine＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Pantoprazole

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Calcium Gluconate

Compatibility depends on specific concentrations or diluents used.

Caution

Labetalol＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Ceftriaxone

Physical precipitation or chemical degradation may occur.

Incompatible

Labetalol＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Labetalol＋Meropenem

Physical precipitation or chemical degradation may occur.

Incompatible

Esmolol＋Pantoprazole

Physical precipitation or chemical degradation may occur.

Incompatible

Esmolol＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Esmolol＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Esmolol＋Magnesium Sulfate

Compatibility depends on specific concentrations or diluents used.

Caution

Esmolol＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Esmolol＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Esmolol＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Esmolol＋Piperacillin/Tazobactam

Physical precipitation or chemical degradation may occur.

Incompatible

Esmolol＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Esmolol＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Nitroglycerin＋Pantoprazole

Precipitates visually (pH dependent).

Incompatible

Nitroglycerin＋Furosemide

Precipitates visually (pH dependent).

Incompatible

Nitroglycerin＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Nitroglycerin＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Nitroglycerin＋Potassium Chloride

Compatibility depends on specific concentrations or diluents used.

Caution

Nitroglycerin＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Nitroglycerin＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Nitroglycerin＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Nitroglycerin＋Vancomycin

Physical precipitation or chemical degradation may occur.

Incompatible

Nitroglycerin＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Pantoprazole

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Calcium Gluconate

Physical precipitation or chemical degradation may occur.

Incompatible

Nitroprusside＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Sodium Bicarbonate

Compatibility depends on specific concentrations or diluents used.

Caution

Nitroprusside＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Nitroprusside＋Meropenem

Physical precipitation or chemical degradation may occur.

Incompatible

Vasopressin＋Pantoprazole

Physical precipitation or chemical degradation may occur.

Incompatible

Vasopressin＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Vasopressin＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Vasopressin＋Magnesium Sulfate

Physical precipitation or chemical degradation may occur.

Incompatible

Vasopressin＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Vasopressin＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Vasopressin＋Ceftriaxone

Compatibility depends on specific concentrations or diluents used.

Caution

Vasopressin＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Vasopressin＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Vasopressin＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Phenylephrine＋Pantoprazole

Precipitates visually (pH dependent).

Incompatible

Phenylephrine＋Furosemide

Precipitates visually (pH dependent).

Incompatible

Phenylephrine＋Calcium Gluconate

Y-site compatible in standard concentrations.

Compatible

Phenylephrine＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Phenylephrine＋Potassium Chloride

Physical precipitation or chemical degradation may occur.

Incompatible

Phenylephrine＋Sodium Bicarbonate

Y-site compatible in standard concentrations.

Compatible

Phenylephrine＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Phenylephrine＋Piperacillin/Tazobactam

Compatibility depends on specific concentrations or diluents used.

Caution

Phenylephrine＋Vancomycin

Y-site compatible in standard concentrations.

Compatible

Phenylephrine＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Milrinone＋Pantoprazole

Y-site compatible in standard concentrations.

Compatible

Milrinone＋Furosemide

Y-site compatible in standard concentrations.

Compatible

Milrinone＋Calcium Gluconate

Physical precipitation or chemical degradation may occur.

Incompatible

Milrinone＋Magnesium Sulfate

Y-site compatible in standard concentrations.

Compatible

Milrinone＋Potassium Chloride

Y-site compatible in standard concentrations.

Compatible

Milrinone＋Sodium Bicarbonate

Physical precipitation or chemical degradation may occur.

Incompatible

Milrinone＋Ceftriaxone

Y-site compatible in standard concentrations.

Compatible

Milrinone＋Piperacillin/Tazobactam

Y-site compatible in standard concentrations.

Compatible

Milrinone＋Vancomycin

Compatibility depends on specific concentrations or diluents used.

Caution

Milrinone＋Meropenem

Y-site compatible in standard concentrations.

Compatible

Ketamine＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Ketamine＋Normal Saline (NS)

Physical precipitation or chemical degradation may occur.

Incompatible

Ketamine＋Lactated Ringer's (LR)

Physical precipitation or chemical degradation may occur.

Incompatible

Ketamine＋Esmolol

Compatibility depends on specific concentrations or diluents used.

Caution

Ketamine＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Ketamine＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Ketamine＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Ketamine＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Ketamine＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Ketamine＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Dextrose 5% (D5W)

Compatibility depends on specific concentrations or diluents used.

Caution

Cisatracurium＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Cisatracurium＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Cisatracurium＋Diltiazem

Physical precipitation or chemical degradation may occur.

Incompatible

Rocuronium＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Rocuronium＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Rocuronium＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Rocuronium＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Rocuronium＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Rocuronium＋Amiodarone

Physical precipitation or chemical degradation may occur.

Incompatible

Rocuronium＋Linezolid

Physical precipitation or chemical degradation may occur.

Incompatible

Rocuronium＋Fluconazole

Compatibility depends on specific concentrations or diluents used.

Caution

Rocuronium＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Rocuronium＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Vecuronium＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Vecuronium＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Vecuronium＋Lactated Ringer's (LR)

Physical precipitation or chemical degradation may occur.

Incompatible

Vecuronium＋Esmolol

Physical precipitation or chemical degradation may occur.

Incompatible

Vecuronium＋Norepinephrine

Compatibility depends on specific concentrations or diluents used.

Caution

Vecuronium＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Vecuronium＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Vecuronium＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Vecuronium＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Vecuronium＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Ondansetron＋Dextrose 5% (D5W)

Physical precipitation or chemical degradation may occur.

Incompatible

Ondansetron＋Normal Saline (NS)

Compatibility depends on specific concentrations or diluents used.

Caution

Ondansetron＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Ondansetron＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Ondansetron＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Ondansetron＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Ondansetron＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Ondansetron＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Ondansetron＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Ondansetron＋Diltiazem

Physical precipitation or chemical degradation may occur.

Incompatible

Metoclopramide＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Metoclopramide＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Metoclopramide＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Metoclopramide＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Metoclopramide＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Metoclopramide＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Metoclopramide＋Linezolid

Physical precipitation or chemical degradation may occur.

Incompatible

Metoclopramide＋Fluconazole

Physical precipitation or chemical degradation may occur.

Incompatible

Metoclopramide＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Metoclopramide＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Famotidine＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Famotidine＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Famotidine＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Famotidine＋Esmolol

Physical precipitation or chemical degradation may occur.

Incompatible

Famotidine＋Norepinephrine

Physical precipitation or chemical degradation may occur.

Incompatible

Famotidine＋Amiodarone

Compatibility depends on specific concentrations or diluents used.

Caution

Famotidine＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Famotidine＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Famotidine＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Famotidine＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Hydromorphone＋Dextrose 5% (D5W)

Physical precipitation or chemical degradation may occur.

Incompatible

Hydromorphone＋Normal Saline (NS)

Physical precipitation or chemical degradation may occur.

Incompatible

Hydromorphone＋Lactated Ringer's (LR)

Compatibility depends on specific concentrations or diluents used.

Caution

Hydromorphone＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Hydromorphone＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Hydromorphone＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Hydromorphone＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Hydromorphone＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Hydromorphone＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Hydromorphone＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Morphine＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Morphine＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Morphine＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Morphine＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Morphine＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Morphine＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Morphine＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Morphine＋Fluconazole

Physical precipitation or chemical degradation may occur.

Incompatible

Morphine＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Morphine＋Diltiazem

Compatibility depends on specific concentrations or diluents used.

Caution

Lorazepam＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Lorazepam＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Lorazepam＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Lorazepam＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Lorazepam＋Norepinephrine

Physical precipitation or chemical degradation may occur.

Incompatible

Lorazepam＋Amiodarone

Physical precipitation or chemical degradation may occur.

Incompatible

Lorazepam＋Linezolid

Compatibility depends on specific concentrations or diluents used.

Caution

Lorazepam＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Lorazepam＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Lorazepam＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Diazepam＋Dextrose 5% (D5W)

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Normal Saline (NS)

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Lactated Ringer's (LR)

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Esmolol

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Norepinephrine

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Amiodarone

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Linezolid

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Fluconazole

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Diazepam＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Diazepam＋Diltiazem

Precipitates in most IV fluids. Give slow IV push closely to the vein insertion.

Incompatible

Haloperidol＋Dextrose 5% (D5W)

Compatibility depends on specific concentrations or diluents used.

Caution

Haloperidol＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Haloperidol＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Haloperidol＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Haloperidol＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Haloperidol＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Haloperidol＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Haloperidol＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Haloperidol＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Haloperidol＋Diltiazem

Physical precipitation or chemical degradation may occur.

Incompatible

Chlorpromazine＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Chlorpromazine＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Chlorpromazine＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Chlorpromazine＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Chlorpromazine＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Chlorpromazine＋Amiodarone

Physical precipitation or chemical degradation may occur.

Incompatible

Chlorpromazine＋Linezolid

Physical precipitation or chemical degradation may occur.

Incompatible

Chlorpromazine＋Fluconazole

Compatibility depends on specific concentrations or diluents used.

Caution

Chlorpromazine＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Chlorpromazine＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Phenytoin＋Dextrose 5% (D5W)

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Normal Saline (NS)

Compatible. Standard diluent/flush for phenytoin.

Compatible

Phenytoin＋Lactated Ringer's (LR)

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Esmolol

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Norepinephrine

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Amiodarone

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Linezolid

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Fluconazole

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Amphotericin B

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Phenytoin＋Diltiazem

Highly incompatible. Precipitates rapidly. Must use NS only as diluent/flush.

Incompatible

Valproic Acid＋Dextrose 5% (D5W)

Physical precipitation or chemical degradation may occur.

Incompatible

Valproic Acid＋Normal Saline (NS)

Compatibility depends on specific concentrations or diluents used.

Caution

Valproic Acid＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Valproic Acid＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Valproic Acid＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Valproic Acid＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Valproic Acid＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Valproic Acid＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Valproic Acid＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Valproic Acid＋Diltiazem

Physical precipitation or chemical degradation may occur.

Incompatible

Levetiracetam＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Levetiracetam＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Levetiracetam＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Levetiracetam＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Levetiracetam＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Levetiracetam＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Levetiracetam＋Linezolid

Physical precipitation or chemical degradation may occur.

Incompatible

Levetiracetam＋Fluconazole

Physical precipitation or chemical degradation may occur.

Incompatible

Levetiracetam＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Levetiracetam＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Thiamine＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Thiamine＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Thiamine＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Thiamine＋Esmolol

Physical precipitation or chemical degradation may occur.

Incompatible

Thiamine＋Norepinephrine

Physical precipitation or chemical degradation may occur.

Incompatible

Thiamine＋Amiodarone

Compatibility depends on specific concentrations or diluents used.

Caution

Thiamine＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Thiamine＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Thiamine＋Amphotericin B

Y-site compatible in standard concentrations.

Compatible

Thiamine＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Multivitamin＋Dextrose 5% (D5W)

Physical precipitation or chemical degradation may occur.

Incompatible

Multivitamin＋Normal Saline (NS)

Physical precipitation or chemical degradation may occur.

Incompatible

Multivitamin＋Lactated Ringer's (LR)

Compatibility depends on specific concentrations or diluents used.

Caution

Multivitamin＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Multivitamin＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Multivitamin＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Multivitamin＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Multivitamin＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Multivitamin＋Amphotericin B

Y-site compatible in standard concentrations.

Compatible

Multivitamin＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Norepinephrine

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Amiodarone

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Linezolid

Y-site compatible in standard concentrations.

Compatible

Folic Acid＋Fluconazole

Physical precipitation or chemical degradation may occur.

Incompatible

Folic Acid＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Folic Acid＋Diltiazem

Compatibility depends on specific concentrations or diluents used.

Caution

Cyanocobalamin＋Dextrose 5% (D5W)

Y-site compatible in standard concentrations.

Compatible

Cyanocobalamin＋Normal Saline (NS)

Y-site compatible in standard concentrations.

Compatible

Cyanocobalamin＋Lactated Ringer's (LR)

Y-site compatible in standard concentrations.

Compatible

Cyanocobalamin＋Esmolol

Y-site compatible in standard concentrations.

Compatible

Cyanocobalamin＋Norepinephrine

Physical precipitation or chemical degradation may occur.

Incompatible

Cyanocobalamin＋Amiodarone

Physical precipitation or chemical degradation may occur.

Incompatible

Cyanocobalamin＋Linezolid

Compatibility depends on specific concentrations or diluents used.

Caution

Cyanocobalamin＋Fluconazole

Y-site compatible in standard concentrations.

Compatible

Cyanocobalamin＋Amphotericin B

Amphotericin B is incompatible with saline and many drugs. Flush line with D5W before and after.

Incompatible

Cyanocobalamin＋Diltiazem

Y-site compatible in standard concentrations.

Compatible

Clinical Warning: This compatibility data is provided for educational reference only. Always consult your institutional pharmacist or official references (e.g., Trissel's) before administering multiple IV medications.

Physical compatibility (lack of precipitate) does not guarantee chemical stability.