ANCA (Anti-Neutrophil Cytoplasmic Antibodies)

Rheumatology

Normal Reference Ranges

Adult

Negative Qualitative

Pediatric

Negative Qualitative

Clinical Significance

Used to diagnose small-vessel vasculitides. Must be differentiated into c-ANCA (PR3) and p-ANCA (MPO) for specific diagnosis.

Causes of High

  • Granulomatosis with polyangiitis (c-ANCA/PR3)
  • Microscopic polyangiitis (p-ANCA/MPO)
  • Eosinophilic granulomatosis with polyangiitis (p-ANCA)
  • Ulcerative Colitis (p-ANCA)

Causes of Low

  • Normal finding