Normal Reference Ranges
Adult
0.5 - 2.0 ng/mL
Pediatric
0.5 - 2.0 ng/mL
Clinical Significance
Cleaved from proinsulin. Helps differentiate endogenous insulin production (Insulinoma) from exogenous insulin administration (surreptitious injection).
Causes of High
- Insulinoma
- Type 2 Diabetes (early stage insulin resistance)
- Renal failure
Causes of Low
- Type 1 Diabetes (beta cell destruction)
- Exogenous insulin administration (factitious hypoglycemia)