Normal Reference Ranges
Adult
Male: 55-170 | Female: 30-135 U/L
Pediatric
Varies by age and muscle mass U/L
Clinical Significance
Enzyme found heavily in skeletal muscle, heart, and brain. Extreme elevations (>5,000 U/L) strongly suggest rhabdomyolysis and risk of acute kidney injury.
Causes of High
- Rhabdomyolysis
- Myocardial Infarction
- Muscular dystrophy
- Severe exercise
- Trauma/Crush injury
- Statin myopathy
Causes of Low
- Decreased muscle mass
- Sedentary lifestyle