Normal Reference Ranges
Adult
Male: 0.7 - 1.3 | Female: 0.6 - 1.1 mg/dL
Pediatric
0.2 - 0.7 (varies by age/muscle mass) mg/dL
Clinical Significance
Breakdown product of creatine phosphate in muscle. Highly specific indicator of renal function (glomerular filtration rate).
Causes of High
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Dehydration
- Rhabdomyolysis
- High meat intake
Causes of Low
- Decreased muscle mass
- Severe liver disease
- Pregnancy