Normal Reference Ranges
Adult
100 - 400 (Target dependent on organ/time post-transplant) ng/mL
Pediatric
Same as adult ng/mL
Clinical Significance
Monitors immunosuppressive therapy. High levels cause nephrotoxicity, hypertension, hirsutism, and gingival hyperplasia.
Causes of High
- Cyclosporine toxicity
- Drug interactions
Causes of Low
- Subtherapeutic dosing
- Non-compliance