Normal Reference Ranges
Adult
200 - 400 mg/dL
Pediatric
150 - 300 mg/dL
Clinical Significance
Essential protein for clot formation (converted to fibrin by thrombin). Low levels in a bleeding patient (like in DIC) often require cryoprecipitate.
Causes of High
- Acute inflammation (Acute phase reactant)
- Pregnancy
- Malignancy
- Trauma
Causes of Low
- DIC (Disseminated Intravascular Coagulation)
- Severe liver disease
- Massive transfusion