Normal Reference Ranges
Adult
< 2.0 (Target dependent on dosing protocol) mcg/mL
Pediatric
< 1.0 mcg/mL
Clinical Significance
Monitors clearance of aminoglycoside. Elevated trough levels indicate accumulator toxicity risking irreversible vestibular/cochlear damage and acute tubular necrosis.
Causes of High
- Renal impairment
- Imminent nephrotoxicity/ototoxicity
Causes of Low
- Normal finding (subtherapeutic does not apply to trough as target is trough clearance)