Normal Reference Ranges
Adult
0.3 - 0.7 (Therapeutic range) IU/mL
Pediatric
0.3 - 0.7 (Therapeutic range) IU/mL
Clinical Significance
Measures plasma heparin concentration by assessing inhibition of Factor Xa. Preferred monitoring standard for unfractionated heparin in patients with baseline elevated aPTT or heparin resistance.
Causes of High
- Heparin overdose
- Renal impairment
Causes of Low
- Subtherapeutic heparin dosing
- Inadequate anticoagulation